Professor Fine has unleashed a virus that will kill millions. Clark must put a stop to him, while Lex wonders what will happen when he tells Lana his latest secret.

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Clark and Martha are both visited by Jonathan’s ghost, who warns them about Lionel and claims that Clark must kill him to stop him. Meanwhile Fine will do whatever it takes to get the vaccine from Lex.
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Clark saves a man who in gratitude decides to help Clark in return…by using his ability to turn invisible and his skill as a hitman to kill Lex so Clark can reunite with Lana. And Clark and Lana finally square off about Lana’s new relationship.

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Lionel is taken hostage by a masked man who forces him to play elaborate games for the prize of staying alive. Martha goes to confront Lionel after Clark tells her Lionel knows his secret and becomes a part of the game herself, fighting for her life.
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Clark befriends a little girl who has the ability to telekinetically shatter glass, then comes to her aid when it’s believed she killed her mother in a brutal stabbing attack. Meanwhile Lex and Lana grow closer together and Chloe finds out about it.

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Distraught over her break-up with Clark, Lana goes to a rogue medical student who experiments with a dangerous kryptonite-based serum that allows people to flat-line but see their dead loved ones. Lana attempts to see her dead parents using the serum and when Clark returns from Honduras to help her, the doctor injects him with the serum and Clark speaks with his dead father…who warns him that Lionel knows his secret. Meanwhile, Lionel continues working to get closer to Martha, and Lex has a near-death vision of his mother.

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Lex (Michael Rosenbaum) discovers that Professor Fine, aka Brainiac (guest star James Marsters) is in Honduras and sets out to confront him. Clark (Tom Welling) meets a beautiful seductress named Simone (Nichole Hiltz) who uses a magical charm to make people succumb to her every wish. An enchanted Clark reveals his powers to Simone, who seizes the opportunity and demands that Clark kill Lex. Kristin Kreuk, Erica Durance, Allison Mack, John Glover and Annette O’Toole also star.

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A sympathetic doctor releases a half-human/half-machine subject named Victor (guest star Lee Thompson Young) who was being held captive and experimented on by LuthorCorp. While making his escape, Victor is struck by Lana’s (Kristin Kreuk) car. After watching him walk away without a scratch, Lana calls Clark (Tom Welling) to investigate. Clark befriends Victor and promises to help him find his girlfriend, but Lex (Michael Rosenbaum) traps Victor and takes him back to LuthorCorp. Erica Durance, Allison Mack, John Glover, Annette O’Toole and John Schneider also star.

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Chloe is possessed by the spirit of a young girl whose body is sealed in the Talon’s walls, and goes searching for the girl’s killer while Clark and Lois try to track her down.

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Clark discovers that the new assistant at the Daily Planet, a bespectacled, bumbling woman named Andrea, is actually a mysterious female vigilante who stalks Suicide Slum. Her path crosses Clark’s as they both seek the same criminal. Meanwhile, Clark’s bottled-up grief threatens to get the best of him and LuthorCorp experiences a shakeup.

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